Publications
Here you find all publications at NCBI Library, Google Scholar, or ORCID.
2024
Busetto, V., Pshanichnaya, L., Lichtenberger, R., Hann, S., Ketting, R. F., and Falk, S. (2024) MUT-7 exoribonuclease activity and localization are mediated by an ancient domain. Nucleic Acids Res 52: 9076–9091. https://doi.org/10.1093/nar/gkae610
Previously published on bioRxiv: https://doi.org/10.1101/2023.12.20.572533
Ketting, R. & Falk, S. (2024) PUCH: eine neuartige Endoribonuklease in der piRNA-Biogenese. BIOspektrum. 10.1007/s12268-024-2086-0. https://rdcu.be/dyFfm
2023
Podvalnaya N.#, Bronkhorst A.W.#, Lichtenberger R., Hellmann S., Nischwitz E., Falk T., Karaulanov E., Butter F., Falk S.*, Ketting R.* (2023) piRNA processing by a trimeric Schlafen-domain nuclease. Nature 622: 402–409. doi:10.1038/s41586-023-06588-2. PMID: 37758951 # equally contributed; *Shared correspondence
Previously published on bioRxiv: link to the preprint
2022
Holzer E., Rumpf-Kienzl C., Falk S., Dammermann A. (2022) A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. PLoS Genet. 18(4):e1010150. PMID: 35442950
Previously published on bioRxiv: https://www.biorxiv.org/content/10.1101/2021.12.20.473533v1
Baudrimont A., Paouneskou D., Mohammad A., Lichtenberger R., Blundon J., Kim Y., Hartl M., Falk S., Schedl T., and Jantsch V. (2022) Release of CHK-2 from PPM-1.D anchorage schedules meiotic entry. Sci Adv. 8, eabl8861. PMID: 35171669
Previously published on bioRxiv: https://www.biorxiv.org/content/10.1101/2021.08.02.453806v1
2021
Perez-Borrajero C., Podvalnaya N.#, Holleis K.#, Lichtenberger R., Basquin J., Hennig J.*, Ketting R.F.*, Falk S.* (2021) Structural basis of PETISCO complex assembly during piRNA biogenesis in C. elegans. Genes Dev. # equally contributed; *Shared correspondence PMID: 34413138
Previously published on bioRxiv: https://www.biorxiv.org/content/10.1101/2021.05.20.444926v2
Cánovas-Márquez, J.T., Falk, S.*, Nicolás, F.E., Padmanabhan, S., Zapata-Pérez, R., Sánchez-Ferrer,A., Navarro,E.* and Garre, V.*(2021) A ribonuclease III involved in virulence of Mucorales fungi has evolved to cut exclusively single-stranded RNA. Nucleic Acid Research *Shared correspondence PMID: 33877360
2020
Lingaraju, M., Schuller, J. M., Falk, S., Gerlach, P., Bonneau, F., Basquin, J., Benda, C., and Conti, E. (2020) To Process or to Decay: A Mechanistic View of the Nuclear RNA Exosome. Cold Spring Harb. Symp. Quant. Biol. PMID: 32493762
Keidel, A., Conti, E. and Falk, S. (2020) Purification and Reconstitution of the S. cerevisiae TRAMP and Ski Complexes for Biochemical and Structural Studies. Methods Mol Biol 2062, 491-513. PMID: 31768992
2019
Lingaraju, M., Johnsen, D., Schlundt, A., Langer, L.M., Basquin, J., Sattler, M., Jensen, T.H., Falk, S.* and Conti, E.* (2019). The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs. Nature Communications 10, 3393. *Shared correspondence PMID: 31358741
2018
Gerlach, P., Schuller, J.M., Bonneau, F., Basquin, J., Reichelt, P., Falk, S.and Conti, E. (2018). Distinct and evolutionary conserved structural features of the human nuclear exosome complex. eLife 2018; 7:e38686. PMID: 30047866
Schuller, J.M.*, Falk, S.*, Fromm, L., Hurt, E. and Conti, E. (2018). Structure of the nuclear exosome captured on a maturing pre-ribosome. Science Apr 13; 360, 219-222 PMID: 29519915
2017
Falk, S., Tants, J.-N., Basquin, J., Thoms, M., Hurt, E., Sattler, M., and Conti, E. (2017). Structural insights into the interaction of the nuclear exosome helicase Mtr4 with the pre-ribosomal protein Nop53. RNA 23, 1780–1787. PMID: 28883156
Fromm, L., Falk, S., Flemming, D., Schuller, J.M., Thoms, M., Conti, E., Hurt, E. (2017). Reconstitution of the complete pathway of ITS2 processing at the pre-ribosome. Nature Communications 8, 1787. PMID: 29176610
Falk, S., Ebert, J., Kögel, A, Bonneau, F. and Conti, E. (2017). Mpp6 incorporation into the nuclear exosome contributes to RNA channeling through the Mtr4 helicase.Cell Reports 20, 2279–2286. PMID: 28877463
2016
Falk, S.*, Finogenova, K.*, Melko, M., Benda, C., Lykke-Andersen, S., Jensen, T. H., and Conti, E. (2016). Structure of the RBM7-ZCCHC8 core of the NEXT complex reveals connections to splicing factors. Nature Communications 7, 13573 PMID: 27905398
2015
Ozgur, S., Buchwald, G., Falk, S., Chakrabarti, S., Prabu, J.R., and Conti, E. (2015). The conformational plasticity of eukaryotic RNA-dependent ATPases. FEBS J. 282, 850–863. PMID: 25645110
2014
Schuch, B., Feigenbutz, M., Makino, D. L., Falk, S., Basquin, C., Mitchell, P., and Conti, E. (2014). The exosome-binding factors Rrp6 and Rrp47 form a composite surface for recruiting the Mtr4 helicase. EMBO J. 33, 2829–2846. PMID: 25319414
Falk, S.*, Weir, J. R.*, Hentschel, J., Reichelt, P., Bonneau, F., and Conti, E. (2014). The molecular architecture of the TRAMP complex reveals the organization and interplay of its two catalytic activities.Molecular Cell 55, 856–867. PMID: 25175027
Lauinger, L., Diernfellner, A., Falk, S., and Brunner, M. (2014). The RNA helicase FRH is an ATP-dependent regulator of CK1a in the circadian clock of Neurospora crassa. Nature Communications 5, 3598–10. PMID: 24710172
2013
van Noort, V., Bradatsch, B., Arumugam, M., Amlacher, S., Bange, G., Creevey, C., Falk, S., Mende, D. R., Sinning, I., Hurt, E., and Bork, P. (2013). Consistent mutational paths predict eukaryotic thermostability. BMC Evol. Biol. 13, 7. PMID: 23305080
2011
Pietrosiuk, A., Lenherr, E. D., Falk, S., Bönemann, G., Kopp, J., Zentgraf, H., Sinning, I., and Mogk, A. (2011). Molecular basis for the unique role of the AAA+ chaperone ClpV in type VI protein secretion. J. Biol. Chem. 286, 30010–30021. PMID: 21733841
2010
Falk, S., and Sinning, I. (2010). The C-terminus of Alb3 interacts with the chromodomains 2 and 3 of cpSRP43. J. Biol. Chem. 285, author reply le26–8. PMID: 21186296
Falk, S., and Sinning, I. (2010) cpSRP43 is a novel chaperone specific for light-harvesting chlorophyll a,b-binding proteins. J. Biol. Chem. 285, 21655–21661. PMID: 20498370
Falk, S., Ravaud, S., Koch, J., and Sinning, I. (2010). The C-terminus of the Alb3 membrane insertase recruits cpSRP43 to the thylakoid membrane. J. Biol. Chem. 285, 5954–5962. PMID: 20018841